Rome has been building on top of itself for more than two thousand years, and you can see the layers: a market square that follows the outline of an emperor's stadium, a Baroque church on older foundations, a temple that became a church and never closed. Rome also has another country inside it. Vatican City is a separate state, but the Vatican Museums and St Peter's belong to any real visit, so they get a day of their own here.
Rome is not a city you finish, so the honest way to see it is to pick your fights. Five days gives you four city days, one easy day trip, and slack for the things that go wrong here: a closed church, a queue, a sudden rain. The unpleasant part is logistics. The Colosseum, the Vatican Museums and the Borghese Gallery need a booked time, the Pantheon (7 EUR since July 2026) and the Trevi Fountain basin (2 EUR since February 2026) charge a fee, and the Colosseum park shortens its hours from 25 October.
The plan keeps each day in one area. Day one is the Colosseum, the Forum and the Palatine, day two the Vatican and the river, day three the Pantheon, Piazza Navona, the old Jewish quarter and Trastevere, day four the Borghese Gallery, the Spanish Steps and the Trevi Fountain, and day five a day trip to the ancient port of Ostia Antica. Start on a Tuesday if you can: the Borghese Gallery and Ostia Antica are closed on Mondays, and the Vatican Museums are closed on Sundays except the last one of the month. More on the country in our guide to Italy.