Salta calls itself la Linda, "the pretty one", and for once the nickname isn't marketing. The city was founded on 16 April 1582 by Hernando de Lerma as a way station between Lima and Buenos Aires, and between 1816 and 1821 it was the front line of the independence war, led by General Martín Miguel de Güemes. What's left is a low colonial center around one arcaded square, with a cathedral, a cabildo and a museum that holds three Inca children frozen in time. The mountains start where the streets end.
Salta is also the base for the best road trip in northwest Argentina. North of it the Quebrada de Humahuaca, a UNESCO valley about 155 km long, runs through striped hills, adobe villages and a pre-Inca fortress, and a side road climbs to a white salt desert at 3,450 m. South of it the Conchas canyon leads to Cafayate, where vineyards grow at heights most wine regions never reach. Five days is a sprint for all this, and you'll spend a lot of it in a car or a minibus. It works because the loop is simple and every day has one big landscape.
The plan: day one is Salta itself, day two Purmamarca and the Salinas Grandes with a night in Tilcara, day three the Pucará, Humahuaca and the Hornocal hills, day four the drive back with a peña night, and day five Cafayate. Start on a Tuesday: the museum of the Inca children is closed on Mondays, and day four then lands on a Friday, a good night for a folk-music peña. This guide is built for a car or a driver, with bus and tour notes in the tips. For the wine region on the other side of the country, see 5 Days in Mendoza, and for the rest of the trip see Argentina.